Leukocyte Kinetics in Hematologic Disorders Studied by DNA-Phosphorus Labeling

Leukocyte kinetics studied by nitrogen mustard induced alterations in DNA phosphorus labeling.

By RICHARD I. WALKER, J. C. HERION AND J. G. PALMER C URRENT EVIDENCE indicates that isotopic labeling of deoxyribonucleic acid ( DNA ) results from synthesis during mitotic interphas&5 and that acquired label is retained until cell death and degradation occur.”5 2 The validity of using inorganic radiophosphorus ( p:oi ) as a leukocyte DNA label rests on these findings. Leukocyte kinetics have ...

Leukocyte Labeling With 51 Chromium . II . Leukocyte Kinetics

Sequential or simultaneous leukocyte kinetic studies using radioactive diisopropylfluorophosphate and radiochromate (31Cr) yielded similar or identical blood leukocyte disappearance curves in seven patients with chronic myelocytic leukemia (CML). Body surface counting regularly showed a rise in the spleen counting rate during the first hours after infusions of granulocyte populations of mixed m...

Leukocyte labeling with 51-chromium. II. Leukocyte kinetics in chronic myelocytic leukemia.

Sequential or simultaneous leukocyte kinetic studies using radioactive diisopropylfluorophosphate and radiochromate (31Cr) yielded similar or identical blood leukocyte disappearance curves in seven patients with chronic myelocytic leukemia (CML). Body surface counting regularly showed a rise in the spleen counting rate during the first hours after infusions of granulocyte populations of mixed m...

Calcium and Phosphorus Metabolism in Growing Pigs Studied by the Balance Technique and Simultaneous Radio-calcium and Radio-phosphorus Kinetics

Abnormal ("ringed") sideroblasts in various hematologic and non-hematologic disorders.